GLP-1 peptides are actually agonists of the Glucagon-like peptide-1 hormone, which is naturally secreted in the intestines of mammals after meals. The primary role of this group of compounds is to regulate blood sugar levels and appetite throughout the day and at night.
The mechanism of action of GLP-1 agonists is based on their action on the beta cells of the pancreas by stimulating the secretion of insulin (a hormone that lowers blood sugar) when the sugar level in the body rises sharply. In addition, these peptides can reduce and slow the secretion of glucagon (a pancreatic hormone opposite to insulin), which increases the secretion of sugar. However, this effect is limited to situations where it is necessary to lower the blood sugar level. In contrast, secretion of the hormone remains the same. This detail is crucial because otherwise the unlimited effect would lead to hypoglycemia, a profound side effect.
Another mechanism of action is to slow gastric emptying into the small intestine. In addition, GLP-1 agonists act on the satiety and hunger center in the hypothalamus (part of the central nervous system). When these two effects are combined, the patient has a prolonged feeling of satiety, which prevents the desire to consume unnecessary calories.
Because of these properties, some of these peptides (Semaglutide, Liraglutide) are considered modern therapies for obesity and metabolic diseases such as Type 2 Diabetes and insulin resistance.
Obesity, and How it Occurs
Obesity is a metabolic disorder characterized by the excessive accumulation of fat deposits in specific parts of the body. The reasons for its development vary, but it is primarily due to excessive calorie intake that cannot be burned off later in the day. However, other etiological factors include hormonal imbalances (Cushing’s Syndrome and hypothyroidism), psychiatric diseases (anxiety disorders, depression, and excessive stress), or the consumption of certain medications (antipsychotics and antidepressants).
Patients diagnosed with obesity experience symptoms such as fatigue, weight gain, bloating, and digestive problems on a daily basis. If left untreated, this condition can progress and cause severe systemic cardiovascular and respiratory disorders, as well as serious gastrointestinal issues.
GLP-1 Therapy for Weight Loss, Main Benefits
Scientific research and clinical trials in humans have demonstrated the significant potential of GLP-1 peptides in treating obesity and metabolic disorders, including Type 2 Diabetes and insulin resistance. The natural GLP-1 hormone is broken down very quickly in the body. Based on clinical research, scientists have developed synthetic versions in the form of peptides that remain in the body longer and exhibit beneficial effects.
The most common method of administering these peptides for weight loss is via subcutaneous injections, typically once daily or weekly. However, new scientific research offers the option of oral capsules as another way of comfortable drug consumption. Based on the described mechanisms of action, GLP-1 agonists reduce appetite, accelerate gastric emptying, and thus regulate blood sugar levels. Your doctor should carefully consider the individual treatment plan, which sometimes requires a year of drug consumption.
The benefits of this peptide therapy are numerous, including significant weight loss, improved appetite regulation, and better control of blood sugar levels. In patients diagnosed with metabolic disorders, cardiovascular complications are common, which in some cases can even lead to death. The results of clinical trials indicate a reduction in the risk of cardiovascular disease after the use of GLP-1 medications.
The benefits of this therapy have also been confirmed in human trials. Patients who participated in the studies noticed significant weight loss, fewer fluctuations in blood sugar levels, and a reduced appetite.
Semaglutide and Weight Loss
Semaglutide is a known GLP-1 agonist used to treat insulin resistance, Type 2 Diabetes, and obesity. The mechanisms of action are similar to those of other agonists. They are based on their effect on the hunger center in the central nervous system, which slows gastric emptying and controls blood sugar levels by acting on pancreatic beta cells. However, certain differences make this peptide specific.
This peptide is administered only once a week, as it has a long half-life, making it very convenient for patients to use. Additionally, Semaglutide has been demonstrated through clinical trials in humans to be one of the most effective treatments for weight loss. Compared to other GLP-1 agonists, this amino acid sequence in its chemical composition undergoes certain modifications, providing stability in the body and increasing its potency.
GLP-1, Best for Weight Loss
GLP-1 agonists are a broad group of compounds that are being actively researched and increasingly used. In medical practice, Semaglutide has proven to be the most successful GLP-1 supplement on the market. Patients who have consumed this peptide have lost up to 15% of their body weight per year, with a reduction in all the accompanying symptoms of obesity.
The Role of a Balanced Diet with GLP1 Therapy
GLP-1 agonists, among other things, work by reducing appetite and producing a feeling of satiety. Although this effect is significant and can accelerate the weight loss process, if a patient does not adhere to a diet and eats unhealthy food, achievement is almost impossible. A balanced diet for weight loss is crucial, as the peptides from this group can help reduce calorie intake. However, their quality still affects the metabolism of fat and sugar.
This type of therapy brings with it specific side effects that are much easier to tolerate if the patient is on a diet. With an unhealthy lifestyle, the metabolism slows down, making it more difficult to digest food and react to change more slowly. After stopping therapy, there is a significantly higher chance that the effect will remain long term in patients who eat healthy foods and who have formed healthy habits, compared to patients who continue to consume unhealthy foods.
GLP-1 Agonists, the Right Choice
If you have been struggling with obesity for years, and it bothers you mentally and physically, GLP-1 agonists may be your ideal choice. This type of peptide therapy is intended for all patients who have been diagnosed with obesity and are ready to adhere to proper use. In addition, patients must develop healthy habits (a balanced diet and physical activity) so that the effects are long term and successful.